Pivaloyl chloride is a branched-chain acyl chloride. It was first made by Aleksandr Butlerov in 1874 by reacting pivalic acid with phosphorus pentachloride. Pivaloyl chloride is an important synthetic intermediate in the chemical industry. It is very widely used in the synthesis of various pharmaceutical products (antiviral agents, anti-inflammatory agents) or plant-protection products (herbicides, insecticides). It is also used in the synthesis of peresters, such as tert-butyl perpivalate and tert-amyl perpivalate, which are used in particular as initiators in radical polymerization. Aryl chloride, are also an important synthetic intermediate, in particular for the preparation of peroxides and peresters, synthesis of various pigments, pesticides or rubber additives.
Pivaloyl chloride can be prepared by the following methods:, i.e. common reagents such as carbonyl chloride (phosgene), sulfuryl chloride, phosphorus trichloride or phosphorus pentachloride, thionyl (II) chloride or oxalyl chloride and pivalic or reacting in the presence of a catalyst involved where carbon monoxide is reacted with t-butyl chloride.
Pharmaceutical Products: Pivaloyl chloride is used as a precursor in the preparation of tert-butyl peroxypivalate, guttiferon A derivatives, which is potential for the treatment of malaria. It is used as a raw material in the production of synthetic acidamide medicament and phenol ester medicament. In addition to this, it is used for the synthesis of active pharmaceutical ingredients such as aminobenzylpenicilin, cephalexin, cefazolin, dipivefrin and dipivalyl epinephrine. It is also used in heavy polymerization, N-acylating agent for amines, Schiff bases, pyrrolidinones as well as an O-acylating agent for alcohols, lactones and saccharides.
Agricultural Chemicals: Pivaloyl chloride is used in the synthesis of plant-protection products (herbicides, insecticides) such as Production of clomazone in the pesticide industry.
Plastics: Pivaloyl chloride is used in the synthesis of peresters, such as tert-butyl perpivalate and tert-amyl perpivalate, which are used in particular as initiators in radical polymerization.