Phthalic Anhydride (99,8%) - India


:   2-Benzofuran-1,3-dione

Cas Number

:   85-44-9

HS Code

:   2917.35.00




Basic Info

Appearance Name

:   Fine White Powder

Common Names

:   Isobenzofuran-1,3-dione, Phthalic anhydride


: 25 KG Plastic Bag, 600 KG Big Plastic Bag

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Technical Document

Brief Overview

Phthalic anhydride, represented by the formula C6H4(CO)2O, serves as the anhydride of phthalic acid and is a significant commercial form of the acid. It marked the pioneering use of a dicarboxylic acid anhydride on a large scale, with this white solid playing a crucial role in industrial chemistry, particularly in the extensive production of plasticizers for plastics. The estimated global production volume in 2000 reached about 3 million tonnes annually.


Manufacturing Process:

Discovered by Auguste Laurent in 1836, phthalic anhydride is currently synthesized through various methods, including the oxidation of naphthalene or ortho-xylene. In these processes, vanadium pentoxide (V2O5) serves as the active oxidant, playing a key role in multiple steps and being regenerated by molecular oxygen. Starting from o-xylene, the oxidation reaction is run at about 320–400 °C and has the following stoichiometry:

C6H4(CH3)2 + 3 O2 → C6H4(CO)2O + 3 H2O

The reaction proceeds with about 70% selectivity. About 10% of maleic anhydride is also produced: C6H4(CH3)2 + 7.5 O2 → C4H2O3 +4 H2O + 4 CO2

Phthalic anhydride and maleic anhydride are recovered by distillation by a series of switch condensers.

The naphthalene route (the Gibbs phthalic anhydride process or the Gibbs–Wohg naphthalene oxidation reaction), a process whose use has declined in compared to the o-xylene route, has the following mechanism:

Phthalic anhydride can also be prepared from phthalic acid by simple dehydration.

Phthalate esters plasticizers:

Phthalic anhydride's primary application lies in being a precursor to phthalate esters, crucial plasticizers for vinyl chloride. These esters, produced through the alcoholysis reaction with phthalic anhydride, reached an annual production of approximately 6.5×109 kg in the 1980s, showcasing an increasing scale each year, all originating from phthalic anhydride. Additionally, it finds significant use in manufacturing polyester resins, along with minor applications in alkyd resins for paints and lacquers, certain gums, insect repellents, and urethane polyester polyols.

Precursor to dyestuffs:

In the realm of dyestuff production, phthalic anhydride is extensively utilized, notably in the synthesis of anthroquinone dye quinizarin through reactions with para-chlorophenol followed by chloride hydrolysis. Phenolphthalein, a well-known compound, results from the condensation of phthalic anhydride with two equivalents of phenol under acidic conditions, hence its name.


In the pharmaceutical sector, phthalic anhydride, when treated with cellulose acetate, yields cellulose acetate phthalate (CAP), a common excipient for enteric coatings. CAP has demonstrated antiviral activity, and phthalic anhydride itself is a degradation product of CAP.

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